EGFR-AKT-SMAD signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction Running title: ID3-mediated glioma stem-like cell genesis and angiogenesis Keywords: Glioma stem cells, Angiogenesis, EGFRvIII, AKT, SMAD, ID3
نویسندگان
چکیده
Authors’ Affiliations: School of Life Sciences and Biotechnology, Korea University; National Research Laboratory of Animal Cell Biotechnology, School of Agricultural Biotechnology, Seoul National University;Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University School of Medicine; Department of Neurosurgery, Samsung Medical Center and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine Republic of Korea
منابع مشابه
EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction.
Aberrant activation of receptor tyrosine kinases (RTK) is causally linked to the pathobiological traits of glioblastoma and genesis of glioma stem-like cells (GSC), but the underlying mechanism is still unknown. Here, we show that epidermal growth factor receptor (EGFR) signaling regulates the proliferation, angiogenesis, and acquisition of GSC characteristics by inducing inhibitor of different...
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تاریخ انتشار 2011